Summary: Researchers provide new insight into the genetic origins of Autism Spectrum Disorder (ASD). The study suggests that, contrary to long-standing beliefs, siblings with ASD may share more of their father’s genome.
The investigation involved the analysis of over 6,000 volunteer families’ genomes, revealing a potential new source of ASD.
Further research may yield new strategies for diagnosis, treatment, and understanding of autism.
- In families with multiple ASD children, the siblings shared more of their father’s genome.
- The research flips a long-standing belief that ASD siblings share more of their mother’s genome.
- This research could potentially change treatment strategies and improve understanding of ASD.
Cold Spring Harbor Laboratory (CSHL) researchers have flipped the script on autism spectrum disorder (ASD) genetics.
Scientists long thought that siblings born with ASD share more of their mother’s genome than their father’s. But CSHL Associate Professor Ivan Iossifov and Professor Michael Wigler have now shown that, in many cases, it’s dad who might be playing a bigger genetic role.
Autism spectrum disorders cover a range of neurological and developmental conditions. They can affect how a person communicates, socializes, learns, and behaves. ASD may also manifest as repetitive behaviors or restricted interests. In the United States, it affects around one in 36 children.
“There are children diagnosed with autism who are high functioning,” Iossifov says. “They have a completely productive life, although they have some minor troubles in social interactions, as most of us do. But also, there are children diagnosed with autism who never learn to speak, and they have definitely a difficult life.”
Over the last two decades, CSHL scientists have led a multimillion-dollar effort to uncover the genetic origins of autism. They discovered thousands of genes that, when damaged, may cause a child to be born with ASD. But their work was not able to account for all cases of ASD. So Iossifov and Wigler set out to find the missing sources.
The duo analyzed the genomes of over 6,000 volunteer families. They found that in families that have two or more children with ASD, the siblings shared more of their father’s genome.
Meanwhile, in families where only one sibling had ASD, the children shared less of their father’s genome. While the discovery reveals a new potential source of ASD, it also poses a provocative question. Could other disorders play by the same genetic rules?
No one is sure how dad’s genome makes its mark on children with ASD. But Iossifov has a couple interesting ideas. He thinks some fathers may carry protective mutations that fail to get passed on.
Or fathers may pass down mutations that trigger the mother’s immune system to attack the developing embryo. Both theories offer hope for parents of children with ASD and other neurological disorders like schizophrenia.
“Our future research is exciting,” Iossifov says. “If one of those theories or two of them prove to be true, then it opens different treatment strategies, which can, in the future, affect quite a lot of families.”
In addition, this research offers helpful tools for educators and therapists. It may allow for earlier diagnoses and a better overall understanding of autis
Sharing parental genomes by siblings concordant or discordant for autism
Studying thousands of families, we find siblings concordant for autism share more of their parental genomes than expected by chance, and discordant siblings share less, consistent with a role of transmission in autism incidence.
The excess sharing of the father is highly significant (p value of 0.0014), with less significance for the mother (p value of 0.31). To compare parental sharing, we adjust for differences in meiotic recombination to obtain a p value of 0.15 that they are shared equally. These observations are contrary to certain models in which the mother carries a greater load than the father.
Nevertheless, we present models in which greater sharing of the father is observed even though the mother carries a greater load.
More generally, our observations of sharing establish quantitative constraints that any complete genetic model of autism must satisfy, and our methods may be applicable to other complex disorders.
Source: Neuro Science